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nothing in particular

    Monday, April 18, 2005

    to anyone who's ever asked me, "wow biological sciences huh? what do you study?", here's a short sample:

    Ag receptor clustering induces Src-family kinase (p) of Tec kinase, which activates PLC-g, which cleaves PIP2 to DAG and IP3. IP3 binds Ca2+ channels in ER to increase cytosolic [CA2+]. decr in Ca2+ causes opening of channels in ER to allow extracell Ca2+ to enter. DAG, tog with incr Ca2+, activate PKC, which can induce IL-2 production. PKC also activates IkK, made up of IkKa and IkKb, to (p) IkB, which is released from NF-kB hence activating NF-kB which can then translocate across membrane to induce cell survival signals Bcl-xL and Bcl-2.
    note: (p) = phosphorylate(s)

    and this's just the easy stuff. it's ok, i don't think i get it either. and no, we don't do dissections.

    // posted by michele @ 4/18/2005 08:37:00 pm
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